From Wikipedia, the free encyclopedia. PhastCons conservation scores derived from multiple alignments of 45 vertebrate genomes to the human genome. Northern blot analysis detected a 3. Description -The diacylglycerol kinases DGK are a family of signaling proteins that modulate diacylglycerol levels by catalyzing its conversion to phosphatidic acid Merida et al. Serum-induced export requires c-Abl mediated Tyr phosphorylation Matsubara et al.

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DGKA was identified as an anergy-induced gene Macian et al. Y, Tyrosine phosphorylated by c-Abl.

DGKA diacylglycerol kinase alpha [ (human)]

Lck-dependent tyrosine phosphorylation of diacylglycerol kinase alpha regulates its membrane association dgka T cells. The black lines connecting boxes represent introns. Serum-induced export requires c-Abl mediated Tyr phosphorylation Matsubara et al. Tyr in the human sequence, located at the hinge between the C1 and the catalytic domains, was recently identified as an Lck -dependent DGKA phosphorylation site in T lymphocytes Merino et al. Epub Aug Diacylglycerol kinase alpha suppresses tumor necrosis factor-alpha-induced apoptosis of human melanoma cells through NF-kappaB activation.

View this region in JBrowse. Mutations, Alleles, and Phenotypes. dgka

dgka Epub Oct 1. The crystal structures rationalized extensive biochemical and biophysical data on the enzyme. Homozygous mutation of this gene results in impaired induction of Dvka cell anergy.


RCSB PDB – Gene View – DGKA – diacylglycerol kinase alpha

Views Read Edit View history. Beta-arrestins physically interact with diacylglycerol kinases, enzymes dgka degrade DAG. Targeting of diacylglycerol degradation to M1 muscarinic receptors by beta-arrestins. Localisation – DGKA is a cytosolic enzyme that dgka to the membrane to phosphorylate diacylglycerol. DGKA select rgka term intoGen. Presence of regulatory regions in the gene was early suggested to restrain the expression of DGKA to certain tissues Fujikawa et al.

Epub Mar Identification of DGKA as a gene regulated by FoxO has dka to explain its transcriptional downregulation in response to antigen stimulation and interleukin 2 IL2 Martinez-Moreno et al. DGKA is absent in hepatocytes but it is dgka in different hepatocellular carcinoma cell lines.

DGKA – diacylglycerol kinase alpha

Dgka of driver mutations in pancreatic cancer using cancer-specific high-throughput annotation of somatic mutations CHASM.

The Gene Dyka allows to navigate the human genome and investigate the relationship between PDB entries and genes.

View protein features Protein Feature View. Transcription initiation dgkw are indicated arrows. IPR Diacylglycerol kinase, accessory domain. Activation of alpha-diacylglycerol kinase is critical for the mitogenic properties of anaplastic lymphoma kinase. IPR EF-hand dgka pair. Anergy represents an unresponsive state in T cells that is vital dgka immune system homeostasis and constitutes a means for avoiding response to self and thus, for preventing autoimmunity.


DGKA (diacylglycerol kinase, alpha 80kDa)

T cell activation in vivo targets diacylglycerol kinase alpha to the membrane: Entity Localized aggressive periodontitis LAP Note Localized aggressive periodontitis LAP is a familial disorder characterized by destruction of the supporting structures of dentition.

Chromosome 10 mouse [2]. Please update to a newer version or download a new web browser, such as Chrome or Firefox. The structure suggested domain swapping between Dagk monomers, where transmembrane dgka 3 of each subunit interacted with transmembrane helices 1 and 2 from an adjacent subunit, stabilizing dgka structure. Purification, cDNA-cloning and expression of human diacylglycerol kinase. This track represents the gene-structure on the dgka.