AU carried out all the work and analyses. Three-dimensional 3D -domain swapping is one of the mechanisms of protein oligomerisation. This explosion of sequence data creates a huge gap among the domains of sequence structure and function, since the experimental techniques to determine the structure and function are very expensive, time taking, and laborious in nature. On 25 December, Tulsi Pujan Diwas is celebrated. Genome-wide prediction and analysis of 3D-domain swapped proteins in the human genome from sequence information. Out of protein sequences, predicted to be involved in 3D-domain swapping and also observed in abiotic stress, only 69 of them are observed to retain homologues of known structure.
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Though daily worship is prescribed, Tuesdays and Fridays are considered especially sacred for Tulsi worship. AU wrote first draft of the manuscript and RS critically read to improve it. On the aggregation of bovine pancreatic ttulsi.
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Mechanisms of photoprotection and nonphotochemical quenching in pea light-harvesting complex at 2. Therefore, there is an urgent need to emphasize on the development of computational approaches in the field of biological systems. Do not have an account? Traditionally, the daily worship and care of the plant is the responsibility of the women of the household. Defense mechanism of plants against biotic stress. The monomeric subunits first undergo partial unfolding to form open conformations, and these open conformations then rulsi domain swapping at high concentrations.
Annu Rev Biophys Biomol Struct. Some of the predicted sequences, which have homologues of known structure, were validated by manual visualization of these structures with the help of PyMol https: Some of the plant protein crystal structures with 3D-domain swapping. Open in a separate window. Structure and catalytic mechanism of a SET domain protein methyltransferase.
These proteins belong to 2 Tulsii families, ie, PF glyceraldehydephosphate dehydrogenase, C-terminal and PF glyceraldehydephosphate dehydrogenase, NAD-binding domain. These proteins bind to specific sites of gene and works as regulatory elements 3c as enhancer.
Declaration of conflicting interests: Those gene products, which were positively predicted for domain swapping in the draft genome of O tenuiflorumwere used as query against UniProt at E -value of 10 for assigning function to these sequences.
In this study, the capacity to engage in domain swapping was predicted from mere sequence information in the whole genome of holy Basil Ocimum tenuiflorumwhich is well known to be an anti-stress agent. Out of protein sequences, predicted to be involved in 3D-domain swapping and also observed in abiotic stress, only 69 of them are observed to retain homologues of known structure.
Studies suggest that around one-third of the proteins in a cell are in oligomeric state. Already have an account? Computational approaches to high-throughput data are gaining importance because of explosion of sequences in the post-genomic era.
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Genome sequencing of herb Tulsi Ocimum tenuiflorum unravels key genes behind its strong medicinal properties. Journal List Bioinform Biol Insights v.
In Orissa, on the first day of the Hindu month Vaishakha April – Maya small vessel with hole at the bottom is filled with water and suspended over the Tulsi plant with a steady stream of water, for the entire month. Data mining in bioinformatics using WEKA. This explosion of sequence data creates a huge gap among the domains of sequence structure and function, since the experimental techniques to determine the structure and function are very expensive, time taking, and laborious in nature.
Festivals A ceremony known as Tulsi Vivah is performed by the Hindus between Prabodhini Ekadashi eleventh lunar day of the waxing moon of Kartika to Kartik Poornima full moon in Kartikausually on the eleventh or the twelfth lunar day. AU carried out all the work and analyses. Click here to view. In this article, all the potential 3D-domain-swapped proteins are reported from the draft genome of Tulsi, 12 along with function elucidation of these proteins for their involvement in different stress tolerance.
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Or also Sign up with. Associated Data Supplementary Materials Supplementary material. It is considered as household god particularly referred as a “Women’s deity”.